shorla oncology inc., - Medication Listings

Imkeldi oral solution contains imatinib mesylate, a kinase inhibitor. Imatinib mesylate is designated chemically as 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2- pyrimidinyl]amino]-phenyl]benzamide methanesulfonate and its structural formula is: The molecular formula is C 29 H 31 N 7 O · CH 4 SO 3 and its molecular weight is 589.7 g/mol. Imatinib mesylate is soluble in aqueous buffers less than or equal to pH 5.5 but is very slightly soluble to insoluble in neutral/alkaline aqueous buffers. In non-aqueous solvents, the drug substance is freely soluble to very slightly soluble in dimethyl sulfoxide, methanol, and ethanol, but is insoluble in n-octanol, acetone, and acetonitrile. Imatinib oral solution is a clear, yellow to brownish yellow colored solution. Each mL of Imkeldi contains the equivalent of 80 mg imatinib present as 95.57 mg imatinib mesylate. Inactive Ingredients: acesulfame potassium, citric acid monohydrate, glycerine, liquid maltitol, purified water, sodium benzoate, strawberry flavor (artificial flavors, lactic acid, triacetin). structure

Methotrexate is a folate analog metabolic inhibitor with the chemical name of N-[4-[[(2,4 diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L glutamic acid. The molecular formula is C 20 H 22 N 8 O 5 and the molecular weight is 454.4 g/mol. The structural formula is: JYLAMVO (methotrexate) oral solution is a clear yellow solution that contains methotrexate, 2 mg/mL. Inactive ingredients include citric acid, ethylparaben, glycerin, methylparaben sodium, orange flavoring powder, polyethylene glycol, purified water, sodium citrate and sucralose. The target pH of the oral solution is 6.8. Structural Formula

Nelarabine Injection is a prodrug of the cytotoxic deoxyguanosine analogue, 9-β- D -arabinofuranosylguanine (ara-G). The chemical name for nelarabine is 2-amino-9-β- D -arabinofuranosyl-6-methoxy-9H-purine. It has the molecular formula C 11 H 15 N 5 O 5 and a molecular weight of 297.27. Nelarabine has the following structural formula: Nelarabine Injection is supplied as a clear, colorless, sterile solution in glass single-dose vials. Each vial contains either 250 mg or 375 mg of nelarabine (5 mg nelarabine per mL) and the inactive ingredient sodium chloride (4.5 mg per mL) in 50 mL or 75 mL, respectively, Water for Injection, USP. Nelarabine Injection is intended for intravenous infusion. Nelarabine is slightly soluble to soluble in water and melts with decomposition between 209ºC and 217ºC. Hydrochloric acid and sodium hydroxide may have been used to adjust the pH. The solution pH ranges from 5.0 to 7.0. structure

TEPYLUTE injection contains thiotepa, an alkylating drug. The chemical name for thiotepa is Tris(1-aziridinyl)phosphine sulfide. Thiotepa has the following structural formula: Thiotepa has the molecular formula C 6 H 12 N 3 PS, and a molecular weight of 189.23, and it appears as fine, white crystalline flakes, with a melting range of 52°C to 57°C. It is soluble in water and organic solvents. Thiotepa is unstable in acid medium. TEPYLUTE (thiotepa) injection is supplied as a sterile solution for intravenous use after dilution. When diluted in water, the resulting solution has a pH of approximately 5.5 to 7.5. TEPYLUTE injection is a 10 mg/mL solution available as: 15 mg/1.5 mL strength single-dose vial contains 15 mg thiotepa and 1.7 g of polyethylene glycol 400 100 mg/10 mL strength multiple-dose vial contains 100 mg thiotepa and 11.3 g of polyethylene glycol 400 structural formula