corium, llc. - Medication Listings

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AZSTARYS SERDEXMETHYLPHENIDATE AND DEXMETHYLPHENIDATE
(SERDEXMETHYLPHE...) 26.1 mg/5.2 mg Capsule
CORIUM, LLC. FDA Rx Only

AZSTARYS (serdexmethylphenidate and dexmethylphenidate) capsules contain dexmethylphenidate, a CNS stimulant, and serdexmethylphenidate, a prodrug of dexmethylphenidate. AZSTARYS capsules are intended for oral administration and each capsule contains a fixed molar ratio of 30% dexmethylphenidate and 70% serdexmethylphenidate. AZSTARYS contains 26.1/5.2, 39.2/7.8, or 52.3/10.4 mg of serdexmethylphenidate/ dexmethylphenidate (equivalent to 28/6, 42/9, or 56/12 mg of serdexmethylphenidate chloride/ dexmethylphenidate hydrochloride, respectively. The combined molar dose of serdexmethylphenidate and dexmethylphenidate in each dosage strength of AZSTARYS is equivalent to 20, 30, or 40 mg dexmethylphenidate hydrochloride, respectively (equivalent to 17.3, 25.9 or 34.6 mg dexmethylphenidate free base, respectively). The chemical name of serdexmethylphenidate chloride is 3-((( 1S )-1-carboxy-2-hydroxyethyl)carbamoyl)-1-(((( 2R )-2-(2-( 1R )-methoxy-2-oxo-1-phenylethyl)piperidine-1-carbonyl)oxy)methyl)pyridinium chloride. Its molecular formula is C 25 H 30 N 3 O 8 + •Cl - , and its structural formula is: Serdexmethylphenidate chloride is a white to off-white crystalline powder. Its solutions are acid to litmus. It is freely soluble in water, soluble in methanol, and slightly soluble in alcohol and acetone. Its molecular weight is 535.98 g/mol. Dexmethylphenidate is the d-threo enantiomer of racemic d,l -methylphenidate hydrochloride. The chemical name of dexmethylphenidate hydrochloride is methyl ( R )-2-phenyl-2-(( R )-piperidin-2-yl)acetate hydrochloride. Its molecular formula is C 14 H 19 NO 2 •HCl, and its structural formula is: Dexmethylphenidate hydrochloride is a white to off-white powder. Its solutions are acid to litmus. It is freely soluble in water and in methanol, soluble in alcohol, and slightly soluble in chloroform and in acetone. Its molecular weight is 269.77 g/mol. Inactive ingredients: colloidal silicon dioxide, crospovidone, hypromellose, magnesium stearate, microcrystalline cellulose, and talc. Each strength capsule also contains colorant ingredients in the capsule shell as follows: 26.1/5.2 mg: Black Iron Oxide, FD&C Blue No. 1, Titanium Dioxide 39.2/7.8 mg: Black Iron Oxide, FD&C Blue No. 1, FD&C Red No. 40, Titanium Dioxide 52.3/10.4 mg: Black Iron Oxide, FD&C Red No. 40, FD&C Yellow No. 6, Titanium Dioxide chemical structure-1 chemical structure-2

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