perphenazine and amitriptyline hydrochloride - Generic Medications

Perphenazine and amitriptyline hydrochloride, a broad spectrum psychotherapeutic agent for the management of outpatients and hospitalized patients with psychoses or neuroses characterized by mixtures of anxiety or agitation with symptoms of depression, is a combination of perphenazine and amitriptyline hydrochloride. Since such mixed syndromes can occur in patients with various degrees of intensity of mental illness, perphenazine and amitriptyline hydrochloride tablets are provided in multiple combinations to afford dosage flexibility for optimum management. Perphenazine is a phenothiazine derivative. The formula is 4-[3-(2-chloro-10 H -phenothiazin-10yl) propyl]-piperazineethanol. Perphenazine, USP is a white, odorless, bitter tasting powder that is insoluble in water. The molecular weight is 403.97. Its structural formula is: Amitriptyline is a dibenzocycloheptadiene derivative. The formula is 10,11-dihydro- N , N -dimethyl-5 H -dibenzo[a,d]cycloheptene-∆ 5 ,γ -propylamine hydrochloride. Amitriptyline hydrochloride, USP is a white, odorless, crystalline compound which is freely soluble in water. The molecular weight is 313.87. Its structural formula is: Each tablet for oral administration contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch (corn), sodium lauryl sulfate and titanium dioxide. The following additional product specific inactive ingredients are employed: 2 mg/10 mg - hydroxypropyl cellulose 2 mg/25 mg - hydroxypropyl cellulose 4 mg/10 mg - polysorbate 80 4 mg/25 mg - hydroxypropyl cellulose 4 mg/50 mg - hydroxypropyl cellulose The following product specific coloring agents are employed: 2 mg/10 mg - calcium sulfate, talc 2 mg/25 mg - D&C Red No. 7 Calcium Lake, FD&C Blue No. 1 Aluminum Lake 4 mg/10 mg - FD&C Blue No. 1 Aluminum Lake 4 mg/25 mg - FD&C Yellow No. 6 Aluminum Lake 4 mg/50 mg - D&C Red No. 7 Calcium Lake, FD&C Blue No. 1 Aluminum Lake Perphenazine Structural Formula Amitriptyline Structural Formula