elbasvir and grazoprevir - Generic Medications
Browse 1 brand name versions of elbasvir and grazoprevir. Review brand names, dosage forms, strengths, and linked product records.
ZEPATIER is a fixed-dose combination tablet containing elbasvir and grazoprevir for oral administration. Elbasvir is an HCV NS5A inhibitor, and grazoprevir is an HCV NS3/4A protease inhibitor. Each tablet contains 50 mg elbasvir and 100 mg grazoprevir. The tablets include the following inactive ingredients: colloidal silicon dioxide, copovidone, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, mannitol, microcrystalline cellulose, sodium chloride, sodium lauryl sulfate, and vitamin E polyethylene glycol succinate. The tablets are film-coated with a coating material containing the following inactive ingredients: carnauba wax, ferrosoferric oxide, hypromellose, iron oxide red, iron oxide yellow, lactose monohydrate, titanium dioxide, and triacetin. Elbasvir: The IUPAC name for elbasvir is Dimethyl N , N' -([(6 S )-6-phenylindolo[1,2- c ][1,3]benzoxazine-3,10-diyl]bis{1 H -imidazole-5,2-diyl-(2 S )-pyrrolidine-2,1-diyl[(2 S )-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate. It has a molecular formula of C 49 H 55 N 9 O 7 and a molecular weight of 882.02. It has the following structural formula: Elbasvir is practically insoluble in water (less than 0.1 mg per mL) and very slightly soluble in ethanol (0.2 mg per mL), but is very soluble in ethyl acetate and acetone. Chemical Structure Grazoprevir: The IUPAC name for grazoprevir is (1a R ,5 S ,8 S ,10 R ,22a R )- N -[(1 R ,2 S )-1-[(Cyclopropylsulfonamido)carbonyl]-2-ethenylcyclopropyl]-14-methoxy-5-(2-methylpropan-2-yl)-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8 H -7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12- b ]quinoxaline-8-carboxamide. It has a molecular formula of C 38 H 50 N 6 O 9 S and a molecular weight of 766.90. It has the following structural formula: Grazoprevir is practically insoluble in water (less than 0.1 mg per mL) but is freely soluble in ethanol and some organic solvents (e.g., acetone, tetrahydrofuran and N,N-dimethylformamide). Chemical Structure
About elbasvir and grazoprevir Generic Drugs
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