Magnesium Sulfate in Water MAGNESIUM SULFATE IN WATER HOSPIRA, INC. FDA Approved Magnesium Sulfate in Water for Injection is a sterile, nonpyrogenic solution of magnesium sulfate heptahydrate in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. The pH is 4.5 (3.5 to 6.5). It is available in 4% and 8% concentrations. See HOW SUPPLIED section for the content and characteristics of available dosage forms and sizes. Magnesium Sulfate, USP heptahydrate is chemically designated MgSO 4 • 7H 2 O, colorless crystals or white powder freely soluble in water. Water for Injection, USP is chemically designated H 2 O. Water can permeate from inside the flexible plastic container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

MAGNESIUM SULFATE IN WATER

Generic: MAGNESIUM SULFATE IN WATER
Mfr: HOSPIRA, INC. FDA Rx Only
FunFoxMeds bottle
Substance Magnesium Sulfate Heptahydrate
Route
INTRAVENOUS
Applications
NDA020309
Product NDC
00409-2050-00 00409-6730-00 00409-6729-00 00409-4121-00 00409-3164-00 00409-5239-00 00409-6730-11 00409-6730-13 00409-6730-50 00409-6730-60 00409-6729-41 00409-6729-23 00409-6729-21 00409-6729-03 00409-6729-31 00409-6729-09 00409-6729-11 00409-6729-24 00409-4121-01 00409-4121-50 00409-2050-01 00409-2050-20 00409-3164-01 00409-3164-12 00409-5239-01 00409-5239-60
Package NDC
0409-6730-11 0409-6730-13 0409-6730-50 0409-6730-60 0409-6729-41 0409-6729-23 0409-6729-21 0409-6729-03 0409-6729-31 0409-6729-09 0409-6729-11 0409-6729-24 0409-4121-01 0409-4121-50 0409-2050-01 0409-2050-20 0409-3164-01 0409-3164-12 0409-5239-01 0409-5239-60

Drug Facts

Composition & Profile

Strengths
4 g/100 ml 40 mg/ml 4 g 4 % 100 ml 20 g/500 ml 20 g 40 g/1000 ml 40 g 2 g/50 ml 50 ml 2 g 4 g/50 ml 80 mg/ml 8 %
Quantities
100 ml 500 ml 1000 ml 50 ml
Treats Conditions
Indications And Usage Magnesium Sulfate In Water For Injection Is Indicated For The Prevention And Control Of Seizures In Preeclampsia And Eclampsia Respectively When Used Judiciously It Effectively Prevents And Controls The Convulsions Of Eclampsia Without Producing Deleterious Depression Of The Central Nervous System Of The Mother Or Infant However Other Effective Drugs Are Available For This Purpose

Identifiers & Packaging

Container Type BOTTLE
NDC 00409-2050-00
All Product Codes
00409-2050-00 00409-6730-00 00409-6729-00 00409-4121-00 00409-3164-00 00409-5239-00 00409-6730-11 00409-6730-13 00409-6730-50 00409-6730-60 00409-6729-41 00409-6729-23 00409-6729-21 00409-6729-03 00409-6729-31 00409-6729-09 00409-6729-11 00409-6729-24 00409-4121-01 00409-4121-50 00409-2050-01 00409-2050-20 00409-3164-01 00409-3164-12 00409-5239-01 00409-5239-60
UNII
SK47B8698T
SPL Set IDs
22ca78b4-f5a3-4144-cf89-5f633acf1e6d
Packaging

HOW SUPPLIED Magnesium Sulfate in Water for Injection is supplied in single-dose flexible plastic containers as follows: NDC Number (Unit of Sale) Concentration Total Magnesium Sulfate As the heptahydrate. Total Magnesium Ion Magnesium Sulfate Concentration Magnesium Ion Concentration Osmolarity (calc.) NDC 0409-6729-23 Case of 24 single-dose flexible plastic containers 4 g/100 mL (40 mg/mL) 4 g 32.5 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-4121-50 Case of 50 single-dose flexible plastic containers 4 g/100 mL (40 mg/mL) 4 g 32.5 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-6729-03 Case of 24 single-dose flexible plastic containers 20 g/500 mL (40 mg/mL) 20 g 162.3 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-2050-20 Case of 20 single-dose flexible plastic containers 20 g/500 mL (40 mg/mL) 20 g 162.3 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-6729-09 Case of 12 single-dose flexible plastic containers 40 g/1000 mL (40 mg/mL) 40 g 325 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-3164-12 Case of 12 single-dose flexible plastic containers 40 g/1000 mL (40 mg/mL) 40 g 325 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-6729-24 Case of 24 single-dose flexible plastic containers 2 g/50 mL Partial fill container 50 mL volume in 100 mL container. (40 mg/mL) 2 g 16.25 mEq 4% (40 mg/mL) 16.25 mEq/50 mL 325 mOsmol/Liter NDC 0409-5239-60 Case of 60 single-dose flexible plastic containers 2 g/50 mL (40 mg/mL) 2 g 16.25 mEq 4% (40 mg/mL) 16.25 mEq/50 mL 325 mOsmol/Liter NDC 0409-6730-13 Case of 24 single-dose flexible plastic containers 4 g/50 mL (80 mg/mL) 4 g 32.5 mEq 8% (80 mg/mL) 32.5 mEq/50 mL 649 mOsmol/Liter NDC 0409-6730-60 Case of 60 single-dose flexible plastic containers 4 g/50 mL (80 mg/mL) 4 g 32.5 mEq 8% (80 mg/mL) 32.5 mEq/50 mL 649 mOsmol/Liter WARNING: DO NOT USE FLEXIBLE CONTAINER IN SERIES CONNECTIONS. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing.; PRINCIPAL DISPLAY PANEL - 50 mL Bag Label 50 mL NDC 0409-6730-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/50 mL (80 mg/mL) 4g TOTAL EACH 50 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 649 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY IM-5199 3 V CONTAINS DEHP Hospira DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 50 mL Bag Label; PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label 50 mL TO OPEN – TEAR AT NOTCH NDC 0409-6730-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/50 mL (80 mg/mL) 4g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 649 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex. Rx only 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA F WR-1551 Hospira PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label; PRINCIPAL DISPLAY PANEL - 50 mL Bag Label - NDC 0409-6730-50 50 mL NDC 0409-6730-50 Magnesium Sulfate in Water for Injection 4 g/50 mL (80 mg/mL) 4g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 649 mOsmol/Liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Rx ONLY 5 PP Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 12165-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 50 mL Bag Label - NDC 0409-6730-50; PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label - NDC 0409-6730-50 50 mL NDC 0409-6730-50 Magnesium Sulfate in Water for Injection 4 g/50 mL (80 mg/mL) 4 g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 649 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex. Rx ONLY 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 13090-01 PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label - NDC 0409-6730-50; PRINCIPAL DISPLAY PANEL - 50 mL Bag Overwrap Back Magnesium Sulfate in Water for Injection 4 g/50 mL (80 mg/mL) 4 g TOTAL 13088-01 PRINCIPAL DISPLAY PANEL - 50 mL Bag Overwrap Back; PRINCIPAL DISPLAY PANEL - 100 mL Bag Label 100 mL NDC 0409-6729-41 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/100 mL (40 mg/mL) 4g TOTAL EACH 100 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY IM-5198 3 V CONTAINS DEHP Hospira DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 100 mL Bag Label; PRINCIPAL DISPLAY PANEL - 100 mL Bag Pouch Label 100 mL TO OPEN – TEAR AT NOTCH NDC 0409-6729-41 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/100 mL (40 mg/mL) 4g TOTAL Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Avoid excessive heat. Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex. Rx only 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA F WR-1550 Hospira PRINCIPAL DISPLAY PANEL - 100 mL Bag Pouch Label; PRINCIPAL DISPLAY PANEL - 500 mL Bag Label 500 mL NDC 0409-6729-21 20 g TOTAL MAGNESIUM SULFATE IN WATER FOR INJECTION 20 g/500 mL (40 mg/mL) EACH 100 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LlTER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY 3 V CONTAINS DEHP Hospira IM-5196 DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 500 mL Bag Label; PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 500 mL TO OPEN TEAR AT NOTCH 2 HDPE DO NOT REMOVE FROM OVERWRAP UNTIL READY FOR USE. AFTER REMOVING THE OVERWRAP, CHECK FOR MINUTE LEAKS BY SQUEEZING CONTAINER FIRMLY. IF LEAKS ARE FOUND, DISCARD SOLUTION AS STERILITY MAY BE IMPAIRED. RECOMMENDED STORAGE: ROOM TEMPERATURE (25°C). AVOID EXCESSIVE HEAT. PROTECT FROM FREEZING. SEE INSERT. 98-4321-R14-3/98 PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 500 mL; PRINCIPAL DISPLAY PANEL - 1000 mL Bag Label 1000 mL NDC 0409-6729-31 MAGNESIUM SULFATE IN WATER FOR INJECTION 40 g TOTAL 40 g/1000 mL (40 mg/mL) EACH 100 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY 3 V CONTAINS DEHP DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA IM-5197 Hospira PRINCIPAL DISPLAY PANEL - 1000 mL Bag Label; PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 1000 mL TO OPEN TEAR AT NOTCH 2 HDPE DO NOT REMOVE FROM OVERWRAP UNTIL READY FOR USE. AFTER REMOVING THE OVERWRAP, CHECK FOR MINUTE LEAKS BY SQUEEZING CONTAINER FIRMLY. IF LEAKS ARE FOUND, DISCARD SOLUTION AS STERILITY MAY BE IMPAIRED. RECOMMENDED STORAGE: ROOM TEMPERATURE (25°C). AVOID EXCESSIVE HEAT. PROTECT FROM FREEZING. SEE INSERT. 98-4321-R14-3/98 PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 1000 mL; PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Label 50 mL NDC 0409-6729-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 2g TOTAL 2 g/50 mL (40 mg/mL) EACH 50 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 2 g (EQUIVALENT TO 16.25 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY 3 V CONTAINS DEHP Hospira IM-5195 DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Label; PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Pouch Label 50 mL TO OPEN – TEAR AT NOTCH NDC 0409-6729-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 2 g TOTAL 2 g/50 mL (40 mg/mL) Each 50 mL contains magnesium sulfate heptahydrate 2 g (equivalent to 16.25 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex Rx only 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA F WR-1549 Hospira PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Pouch Label; PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Label 100 mL NDC 0409-4121-01 Magnesium Sulfate in Water for Injection 4 g TOTAL 4 g/100 mL (40 mg/mL) Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: see prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Rx ONLY 5 PP Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 12137-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Label; PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Pouch Label 100 mL NDC 0409-4121-01 Magnesium Sulfate in Water for Injection 4 g/100 mL (40 mg/mL) 4 g TOTAL Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Avoid excessive heat. Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex Rx ONLY 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 13093-01 PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Pouch Label; PRINCIPAL DISPLAY PANEL - 100 mL Bag Overwrap Back Magnesium Sulfate in Water for Injection 4 g/100 mL (40 mg/mL) 4 g TOTAL 13097-01 PRINCIPAL DISPLAY PANEL - 100 mL Bag Overwrap Back; PRINCIPAL DISPLAY PANEL - 20 g/500 mL Bag Label 500 mL NDC 0409-2050-01 Magnesium Sulfate in Water for Injection 20 g TOTAL 20 g/500 mL (40 mg/mL) Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/Liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: see prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Inspect bag by squeezing firmly. If leaks are found, discard. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. Do not remove from overwrap until ready for use. Rx ONLY 5 PP Hospira Distributed by Hospira, Inc., Lake Forest, IL 60045 USA 12145-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 20 g/500 mL Bag Label; PRINCIPAL DISPLAY PANEL - 40 g/1000 mL Bag Label 1000 mL NDC 0409-3164-01 Magnesium Sulfate in Water for Injection 40 g TOTAL 40 g/1000 mL (40 mg/mL) Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/Liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Inspect bag by squeezing firmly. If leaks are found, discard. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. Do not remove from overwrap until ready for use. Rx ONLY 5 PP Distributed by Hospira, Inc. Lake Forest, IL 60045 USA Hospira 12146-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 40 g/1000 mL Bag Label; PRINCIPAL DISPLAY PANEL -2 g/50 mL Bag Label - 0409-5239 50 mL NDC 0409-5239-01 Magnesium Sulfate in Water for Injection 2 g TOTAL 2 g/50 mL (40 mg/mL) Each 50 mL contains magnesium sulfate heptahydrate 2 g (equivalent to 16.25 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: see prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Rx ONLY 5 PP Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 12136-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Label - 0409-5239; PRINCIPAL DISPLAY PANEL -2 g/50 mL Bag Pouch Label - 0409-5239 50 mL NDC 0409-5239-01 Magnesium Sulfate in Water for Injection 2 g/50 mL (40 mg/mL) 2 g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 2 g (equivalent to 16.25 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex Rx ONLY 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 13092-01 PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Pouch Label - 0409-5239; PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Overwrap Back Magnesium Sulfate in Water for Injection 2 g/50 mL (40 mg/mL) 2 g TOTAL 13091-01 PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Overwrap Back

Package Descriptions
  • HOW SUPPLIED Magnesium Sulfate in Water for Injection is supplied in single-dose flexible plastic containers as follows: NDC Number (Unit of Sale) Concentration Total Magnesium Sulfate As the heptahydrate. Total Magnesium Ion Magnesium Sulfate Concentration Magnesium Ion Concentration Osmolarity (calc.) NDC 0409-6729-23 Case of 24 single-dose flexible plastic containers 4 g/100 mL (40 mg/mL) 4 g 32.5 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-4121-50 Case of 50 single-dose flexible plastic containers 4 g/100 mL (40 mg/mL) 4 g 32.5 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-6729-03 Case of 24 single-dose flexible plastic containers 20 g/500 mL (40 mg/mL) 20 g 162.3 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-2050-20 Case of 20 single-dose flexible plastic containers 20 g/500 mL (40 mg/mL) 20 g 162.3 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-6729-09 Case of 12 single-dose flexible plastic containers 40 g/1000 mL (40 mg/mL) 40 g 325 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-3164-12 Case of 12 single-dose flexible plastic containers 40 g/1000 mL (40 mg/mL) 40 g 325 mEq 4% (40 mg/mL) 32.5 mEq/100 mL 325 mOsmol/Liter NDC 0409-6729-24 Case of 24 single-dose flexible plastic containers 2 g/50 mL Partial fill container 50 mL volume in 100 mL container. (40 mg/mL) 2 g 16.25 mEq 4% (40 mg/mL) 16.25 mEq/50 mL 325 mOsmol/Liter NDC 0409-5239-60 Case of 60 single-dose flexible plastic containers 2 g/50 mL (40 mg/mL) 2 g 16.25 mEq 4% (40 mg/mL) 16.25 mEq/50 mL 325 mOsmol/Liter NDC 0409-6730-13 Case of 24 single-dose flexible plastic containers 4 g/50 mL (80 mg/mL) 4 g 32.5 mEq 8% (80 mg/mL) 32.5 mEq/50 mL 649 mOsmol/Liter NDC 0409-6730-60 Case of 60 single-dose flexible plastic containers 4 g/50 mL (80 mg/mL) 4 g 32.5 mEq 8% (80 mg/mL) 32.5 mEq/50 mL 649 mOsmol/Liter WARNING: DO NOT USE FLEXIBLE CONTAINER IN SERIES CONNECTIONS. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing.
  • PRINCIPAL DISPLAY PANEL - 50 mL Bag Label 50 mL NDC 0409-6730-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/50 mL (80 mg/mL) 4g TOTAL EACH 50 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 649 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY IM-5199 3 V CONTAINS DEHP Hospira DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 50 mL Bag Label
  • PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label 50 mL TO OPEN – TEAR AT NOTCH NDC 0409-6730-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/50 mL (80 mg/mL) 4g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 649 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex. Rx only 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA F WR-1551 Hospira PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label
  • PRINCIPAL DISPLAY PANEL - 50 mL Bag Label - NDC 0409-6730-50 50 mL NDC 0409-6730-50 Magnesium Sulfate in Water for Injection 4 g/50 mL (80 mg/mL) 4g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 649 mOsmol/Liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Rx ONLY 5 PP Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 12165-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 50 mL Bag Label - NDC 0409-6730-50
  • PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label - NDC 0409-6730-50 50 mL NDC 0409-6730-50 Magnesium Sulfate in Water for Injection 4 g/50 mL (80 mg/mL) 4 g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 649 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex. Rx ONLY 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 13090-01 PRINCIPAL DISPLAY PANEL - 50 mL Bag Pouch Label - NDC 0409-6730-50
  • PRINCIPAL DISPLAY PANEL - 50 mL Bag Overwrap Back Magnesium Sulfate in Water for Injection 4 g/50 mL (80 mg/mL) 4 g TOTAL 13088-01 PRINCIPAL DISPLAY PANEL - 50 mL Bag Overwrap Back
  • PRINCIPAL DISPLAY PANEL - 100 mL Bag Label 100 mL NDC 0409-6729-41 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/100 mL (40 mg/mL) 4g TOTAL EACH 100 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY IM-5198 3 V CONTAINS DEHP Hospira DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 100 mL Bag Label
  • PRINCIPAL DISPLAY PANEL - 100 mL Bag Pouch Label 100 mL TO OPEN – TEAR AT NOTCH NDC 0409-6729-41 MAGNESIUM SULFATE IN WATER FOR INJECTION 4 g/100 mL (40 mg/mL) 4g TOTAL Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Avoid excessive heat. Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex. Rx only 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA F WR-1550 Hospira PRINCIPAL DISPLAY PANEL - 100 mL Bag Pouch Label
  • PRINCIPAL DISPLAY PANEL - 500 mL Bag Label 500 mL NDC 0409-6729-21 20 g TOTAL MAGNESIUM SULFATE IN WATER FOR INJECTION 20 g/500 mL (40 mg/mL) EACH 100 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LlTER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY 3 V CONTAINS DEHP Hospira IM-5196 DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 500 mL Bag Label
  • PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 500 mL TO OPEN TEAR AT NOTCH 2 HDPE DO NOT REMOVE FROM OVERWRAP UNTIL READY FOR USE. AFTER REMOVING THE OVERWRAP, CHECK FOR MINUTE LEAKS BY SQUEEZING CONTAINER FIRMLY. IF LEAKS ARE FOUND, DISCARD SOLUTION AS STERILITY MAY BE IMPAIRED. RECOMMENDED STORAGE: ROOM TEMPERATURE (25°C). AVOID EXCESSIVE HEAT. PROTECT FROM FREEZING. SEE INSERT. 98-4321-R14-3/98 PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 500 mL
  • PRINCIPAL DISPLAY PANEL - 1000 mL Bag Label 1000 mL NDC 0409-6729-31 MAGNESIUM SULFATE IN WATER FOR INJECTION 40 g TOTAL 40 g/1000 mL (40 mg/mL) EACH 100 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 4 g (EQUIVALENT TO 32.5 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY 3 V CONTAINS DEHP DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA IM-5197 Hospira PRINCIPAL DISPLAY PANEL - 1000 mL Bag Label
  • PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 1000 mL TO OPEN TEAR AT NOTCH 2 HDPE DO NOT REMOVE FROM OVERWRAP UNTIL READY FOR USE. AFTER REMOVING THE OVERWRAP, CHECK FOR MINUTE LEAKS BY SQUEEZING CONTAINER FIRMLY. IF LEAKS ARE FOUND, DISCARD SOLUTION AS STERILITY MAY BE IMPAIRED. RECOMMENDED STORAGE: ROOM TEMPERATURE (25°C). AVOID EXCESSIVE HEAT. PROTECT FROM FREEZING. SEE INSERT. 98-4321-R14-3/98 PRINCIPAL DISPLAY PANEL - 40 mg/mL Bag Overwrap - 1000 mL
  • PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Label 50 mL NDC 0409-6729-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 2g TOTAL 2 g/50 mL (40 mg/mL) EACH 50 mL CONTAINS MAGNESIUM SULFATE HEPTAHYDRATE 2 g (EQUIVALENT TO 16.25 mEq MAGNESIUM) IN WATER FOR INJECTION. MAY CONTAIN SULFURIC ACID AND/OR SODIUM HYDROXIDE FOR pH ADJUSTMENT. pH 4.5 (3.5 to 6.5) 325 mOsmol/LITER (CALC.) SINGLE-DOSE CONTAINER. DISCARD UNUSED PORTION. FOR INTRAVENOUS USE. RECOMMENDED DOSAGE: SEE PRESCRIBING INFORMATION. STERILE, NONPYROGENIC. USE ONLY IF SOLUTION IS CLEAR AND CONTAINER IS UNDAMAGED. MUST NOT BE USED IN SERIES CONNECTIONS. Rx ONLY 3 V CONTAINS DEHP Hospira IM-5195 DISTRIBUTED BY HOSPIRA, INC., LAKE FOREST, IL 60045 USA PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Label
  • PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Pouch Label 50 mL TO OPEN – TEAR AT NOTCH NDC 0409-6729-11 MAGNESIUM SULFATE IN WATER FOR INJECTION 2 g TOTAL 2 g/50 mL (40 mg/mL) Each 50 mL contains magnesium sulfate heptahydrate 2 g (equivalent to 16.25 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex Rx only 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA F WR-1549 Hospira PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Pouch Label
  • PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Label 100 mL NDC 0409-4121-01 Magnesium Sulfate in Water for Injection 4 g TOTAL 4 g/100 mL (40 mg/mL) Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: see prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Rx ONLY 5 PP Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 12137-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Label
  • PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Pouch Label 100 mL NDC 0409-4121-01 Magnesium Sulfate in Water for Injection 4 g/100 mL (40 mg/mL) 4 g TOTAL Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Avoid excessive heat. Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex Rx ONLY 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 13093-01 PRINCIPAL DISPLAY PANEL - 4 g/100 mL Bag Pouch Label
  • PRINCIPAL DISPLAY PANEL - 100 mL Bag Overwrap Back Magnesium Sulfate in Water for Injection 4 g/100 mL (40 mg/mL) 4 g TOTAL 13097-01 PRINCIPAL DISPLAY PANEL - 100 mL Bag Overwrap Back
  • PRINCIPAL DISPLAY PANEL - 20 g/500 mL Bag Label 500 mL NDC 0409-2050-01 Magnesium Sulfate in Water for Injection 20 g TOTAL 20 g/500 mL (40 mg/mL) Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/Liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: see prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Inspect bag by squeezing firmly. If leaks are found, discard. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. Do not remove from overwrap until ready for use. Rx ONLY 5 PP Hospira Distributed by Hospira, Inc., Lake Forest, IL 60045 USA 12145-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 20 g/500 mL Bag Label
  • PRINCIPAL DISPLAY PANEL - 40 g/1000 mL Bag Label 1000 mL NDC 0409-3164-01 Magnesium Sulfate in Water for Injection 40 g TOTAL 40 g/1000 mL (40 mg/mL) Each 100 mL contains magnesium sulfate heptahydrate 4 g (equivalent to 32.5 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/Liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Inspect bag by squeezing firmly. If leaks are found, discard. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. Do not remove from overwrap until ready for use. Rx ONLY 5 PP Distributed by Hospira, Inc. Lake Forest, IL 60045 USA Hospira 12146-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 40 g/1000 mL Bag Label
  • PRINCIPAL DISPLAY PANEL -2 g/50 mL Bag Label - 0409-5239 50 mL NDC 0409-5239-01 Magnesium Sulfate in Water for Injection 2 g TOTAL 2 g/50 mL (40 mg/mL) Each 50 mL contains magnesium sulfate heptahydrate 2 g (equivalent to 16.25 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. pH 4.5 (3.5 to 6.5) 325 mOsmol/liter (CALC.) Single-dose container. Discard unused portion. For intravenous use. Recommended dosage: see prescribing information. Sterile, nonpyrogenic. Use only if solution is clear and container is undamaged. Must not be used in series connections. Rx ONLY 5 PP Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 12136-02 LOT:12345678 EXP:mm-yyyy PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Label - 0409-5239
  • PRINCIPAL DISPLAY PANEL -2 g/50 mL Bag Pouch Label - 0409-5239 50 mL NDC 0409-5239-01 Magnesium Sulfate in Water for Injection 2 g/50 mL (40 mg/mL) 2 g TOTAL Each 50 mL contains magnesium sulfate heptahydrate 2 g (equivalent to 16.25 mEq magnesium) in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. 325 mOsmol/Liter (CALC.) pH 4.5 (3.5 to 6.5) DO NOT ADD SUPPLEMENTARY MEDICATION. WHENEVER POSSIBLE USE CENTRAL ROUTE. Single-dose container. For intravenous use. Recommended dosage: See prescribing information. Sterile, nonpyrogenic. Use only if solution is clear. After removing the overwrap, check for minute leaks by squeezing container firmly. If leaks are found, discard unit as sterility may be impaired. Must not be used in series connections. The overwrap is a moisture barrier. Do not remove unit from overwrap until ready for use. Use unit promptly when pouch is opened. Store at 20 to 25°C (68 to 77°F). [See USP Controlled Room Temperature.] Protect from freezing. See prescribing information. Not Made With Natural Rubber Latex Rx ONLY 7 OTHER Distributed by Hospira, Inc., Lake Forest, IL 60045 USA Hospira 13092-01 PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Pouch Label - 0409-5239
  • PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Overwrap Back Magnesium Sulfate in Water for Injection 2 g/50 mL (40 mg/mL) 2 g TOTAL 13091-01 PRINCIPAL DISPLAY PANEL - 2 g/50 mL Bag Overwrap Back
Overview

Magnesium Sulfate in Water for Injection is a sterile, nonpyrogenic solution of magnesium sulfate heptahydrate in water for injection. May contain sulfuric acid and/or sodium hydroxide for pH adjustment. The pH is 4.5 (3.5 to 6.5). It is available in 4% and 8% concentrations. See HOW SUPPLIED section for the content and characteristics of available dosage forms and sizes. Magnesium Sulfate, USP heptahydrate is chemically designated MgSO 4 • 7H 2 O, colorless crystals or white powder freely soluble in water. Water for Injection, USP is chemically designated H 2 O. Water can permeate from inside the flexible plastic container into the overwrap but not in amounts sufficient to affect the solution significantly. Solutions in contact with the plastic container may leach out certain chemical components from the plastic in very small amounts; however, biological testing was supportive of the safety of the plastic container materials. Exposure to temperatures above 25°C/77°F during transport and storage will lead to minor losses in moisture content. Higher temperatures lead to greater losses. It is unlikely that these minor losses will lead to clinically significant changes within the expiration period.

Indications & Usage

Magnesium Sulfate in Water for Injection is indicated for the prevention and control of seizures in preeclampsia and eclampsia, respectively. When used judiciously it effectively prevents and controls the convulsions of eclampsia without producing deleterious depression of the central nervous system of the mother or infant. However, other effective drugs are available for this purpose.

Dosage & Administration

Magnesium Sulfate in Water for Injection is intended for intravenous use only. For the management of pre-eclampsia or eclampsia, intravenous infusions of dilute solutions of magnesium (1% to 8%) are often given in combination with intramuscular injections of 50% Magnesium Sulfate Injection, USP. Therefore, in the clinical conditions cited below, both forms of therapy are noted, as appropriate. Continuous maternal administration of magnesium sulfate in pregnancy beyond 5-7 days can cause fetal abnormalities. In Eclampsia In severe pre-eclampsia or eclampsia, the total initial dose is 10 to 14 g of magnesium sulfate. To initiate therapy, 4 g of Magnesium Sulfate in Water for Injection may be administered intravenously. The rate of I.V. infusion should generally not exceed 150 mg/minute, or 3.75 mL of a 4% concentration (or its equivalent) per minute, except in severe eclampsia with seizures. Simultaneously, 4 to 5 g (32.5 to 40.6 mEq) of magnesium sulfate may be administered intramuscularly into each buttock using undiluted 50% Magnesium Sulfate Injection, USP. After the initial I.V. dose, some clinicians administer 1 to 2 g/hour by constant I.V. infusion. Subsequent intramuscular doses of 4 to 5 g of magnesium sulfate may be injected into alternate buttocks every four hours, depending on the continuing presence of the patellar reflex, adequate respiratory function, and absence of signs of magnesium toxicity. Therapy should continue until paroxysms cease. A serum magnesium level of 6 mg/100 mL is considered optimal for control of seizures. A total daily (24 hr) dose of 30 to 40 g magnesium sulfate should not be exceeded. In the presence of severe renal insufficiency, frequent serum magnesium concentrations must be obtained and the maximum dosage of magnesium sulfate is 20 g per 48 hours. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not administer unless solution is clear. Discard unused portion.

Warnings & Precautions
WARNINGS FETAL HARM: Continuous administration of magnesium sulfate beyond 5-7 days to pregnant women can lead to hypocalcemia and bone abnormalities in the developing fetus. These bone abnormalities include skeletal demineralization and osteopenia. In addition, cases of neonatal fracture have been reported. The shortest duration of treatment that can lead to fetal harm is not known. Magnesium sulfate should be used during pregnancy only if clearly needed. If magnesium sulfate is given for treatment of preterm labor, the woman should be informed that the efficacy and safety of such use have not been established and that use of magnesium sulfate beyond 5-7 days may cause fetal abnormalities. Parenteral use in the presence of renal insufficiency may lead to magnesium intoxication.
Contraindications

Intravenous magnesium should not be given to mothers with toxemia of pregnancy during the two hours preceding delivery.

Adverse Reactions

The adverse effects of parenterally administered magnesium usually are the result of magnesium intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to magnesium sulfate therapy for eclampsia has been reported.

Similar Drugs

Related medications based on brand, generic name, substance, active ingredients.

FUROSEMIDE FUROSEMIDE FUROSEMIDE FUROSEMIDE AZITHROMYCIN AZITHROMYCIN CIPROFLOXACIN IN DEXTROSE CIPROFLOXACIN ACETYLCYSTEINE ACETYLCYSTEINE AMIDATE ETOMIDATE AMINOCAPROIC ACID AMINOCAPROIC ACID AMINOPHYLLINE AMINOPHYLLINE ATRACURIUM BESYLATE ATRACURIUM BESYLATE ATROPINE SULFATE ATROPINE SULFATE

View all similar drugs →

Additional Information

View all drugs in this Set View DailyMed Details