Drug Facts
Composition & Profile
Identifiers & Packaging
HOW SUPPLIED Sodium Chloride Injection, USP is available in flip-top glass vials. Product No. NDC No. % NaCl Na + mEq/mL Cl - mEq/mL mOsmol/ mL Fill Volume mL 13920 63323-139-20 14.6 2.5 2.5 5 20 13940 63323-139-40 14.6 2.5 2.5 5 40 These vials are Single Dose Vials; packaged 25 vials per tray. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Do not permit to freeze.; PACKAGE LABEL - PRINCIPAL DISPLAY - Sodium Chloride 40 mL Vial Label NDC 63323-139-40 13940 Sodium Chloride Injection, USP Concentrated 14.6% (2.5 mEq/mL) For IV Use Only After Dilution Rx only 40 mL Single Dose Vial nacl-label-01.jpg
- HOW SUPPLIED Sodium Chloride Injection, USP is available in flip-top glass vials. Product No. NDC No. % NaCl Na + mEq/mL Cl - mEq/mL mOsmol/ mL Fill Volume mL 13920 63323-139-20 14.6 2.5 2.5 5 20 13940 63323-139-40 14.6 2.5 2.5 5 40 These vials are Single Dose Vials; packaged 25 vials per tray. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Do not permit to freeze.
- PACKAGE LABEL - PRINCIPAL DISPLAY - Sodium Chloride 40 mL Vial Label NDC 63323-139-40 13940 Sodium Chloride Injection, USP Concentrated 14.6% (2.5 mEq/mL) For IV Use Only After Dilution Rx only 40 mL Single Dose Vial nacl-label-01.jpg
Overview
Sodium Chloride Injection, USP is a sterile, nonpyrogenic, concentrated solution for intravenous administration ONLY AFTER DILUTION to replenish electrolytes. The preparation contains 2.5 mEq/mL (14.6%) sodium chloride, in Water for Injection. The solution contains no bacteriostat, antimicrobial agent or added buffer; pH of the solution ranges from 4.5 to 7.0. Each mL contains: Sodium chloride 146 mg; Water for Injection q.s. pH may have been adjusted with hydrochloric acid. The osmolar concentration of the 2.5 mEq/mL solution is 5 mOsmol/mL. Sodium chloride is chemically designated NaCI, a white crystalline compound freely soluble in water.
Indications & Usage
Sodium Chloride Injection, USP is indicated for parenteral restoration of sodium ion in patients with restricted oral intake. Sodium replacement is specifically indicated in patients with hyponatremia or low salt syndrome. Sodium chloride injection may also be added to compatible carbohydrate solutions such as dextrose in water to provide electrolytes.
Dosage & Administration
Sodium chloride injection is administered intravenously only after addition to a larger volume of fluid . The dose, dilution and rate of injection are dependent upon the individual needs of each patient. All or part of the contents of one or more additive containers may be added to an intravenous solution container. Concentrations of up to 5% sodium chloride have been administered. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (See PRECAUTIONS .)
Warnings & Precautions
WARNINGS WARNING: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration. Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention. In patients with diminished renal function, administration of solutions containing sodium may result in sodium retention. The intravenous administration of this solution (after appropriate dilution) can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, congested states or pulmonary edema. Excessive administration of potassium free solutions may result in significant hypokalemia.
Contraindications
Sodium chloride injection is contraindicated in patients with hypernatremia or fluid retention.
Adverse Reactions
None known.
Similar Drugs
Related medications based on brand, generic name, substance, active ingredients.