Drug Facts
Composition & Profile
Identifiers & Packaging
HOW SUPPLIED Chlorhexidine gluconate oral rinse is supplied as a blue liquid in 4-oz (118 mL) and 1-pint (473 ml) amber plastic bottles with child-resistant dispensing closures. Store at 20°C to 25°C (68°F-77°F), excursions permitted to 15°C to 30°C (59°F to 86°F) [See USP controlled Room Temperature]. Rx Only Revised: August 2023 Distributed by: Benco Dental 800.GO.BENCO • benco.com 295 CenterPoint Blvd., Pittston, PA 18640, Made in USA; NDC: 66975-600-04 Benco Dental GIBSON HEALTHCARE Chlorhexdine Gluconate 0.12% Oral Rinse, USP DIRECTIONS FOR USE: Swish 1 tablespoon (15 ml) in mouth undiluted for 30 seconds, then spit out. Use after breakfast and before bedtime. Or, use as prescribed. NOTE: To minimize medicinal taste, do not rinse with water immediately after use. Rx Only INGREDIENTS: 0.12% chlorhexidine gluconate in a base containing water, 11.6% alcohol, glycering, PEG-40 sorbitan diisostearate, flavor, sodium saccharin and FD&C Blue No. 1. To open, press down while turing cap. To reseal, turn cap past "clicks" until tightly locked. [5466-024] 4 oz. (118ml) 1999BEN04EZCD NDC #66975-600-16 GIBSON HEALTHCARE CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE, USP DIRECTIONS FOR USE: Fill cap to the "fill line" (15 ml). Swish in mouth undiluted for 30 seconds, then spit out. Use after breakfast and before bedtime. Or, use as prescribed. NOTE: Do not rinse with water immediately after use. INGREDIENTS: 0.12% chlorhexidine gluconate in a base containing water, 11.6% alcohol, glycering, PEG-40 sorbitan diisostearate, flavor, sodium saccharin and FD&C Blue No. 1. To open, press down while turing cap. To reseal, turn cap past "clicks" until tightly locked. Rx Only KEEP OUT OF REACH OF CHILDREN 1 Pint (473 mL) Reorder # [4487-638] 1999BEN16EZCDA Benco 4oz 1 Benco 4oz 2 label Benco 16oz 1 label Benco 16oz 3 Benco 16oz 4
- HOW SUPPLIED Chlorhexidine gluconate oral rinse is supplied as a blue liquid in 4-oz (118 mL) and 1-pint (473 ml) amber plastic bottles with child-resistant dispensing closures. Store at 20°C to 25°C (68°F-77°F), excursions permitted to 15°C to 30°C (59°F to 86°F) [See USP controlled Room Temperature]. Rx Only Revised: August 2023 Distributed by: Benco Dental 800.GO.BENCO • benco.com 295 CenterPoint Blvd., Pittston, PA 18640, Made in USA
- NDC: 66975-600-04 Benco Dental GIBSON HEALTHCARE Chlorhexdine Gluconate 0.12% Oral Rinse, USP DIRECTIONS FOR USE: Swish 1 tablespoon (15 ml) in mouth undiluted for 30 seconds, then spit out. Use after breakfast and before bedtime. Or, use as prescribed. NOTE: To minimize medicinal taste, do not rinse with water immediately after use. Rx Only INGREDIENTS: 0.12% chlorhexidine gluconate in a base containing water, 11.6% alcohol, glycering, PEG-40 sorbitan diisostearate, flavor, sodium saccharin and FD&C Blue No. 1. To open, press down while turing cap. To reseal, turn cap past "clicks" until tightly locked. [5466-024] 4 oz. (118ml) 1999BEN04EZCD NDC #66975-600-16 GIBSON HEALTHCARE CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE, USP DIRECTIONS FOR USE: Fill cap to the "fill line" (15 ml). Swish in mouth undiluted for 30 seconds, then spit out. Use after breakfast and before bedtime. Or, use as prescribed. NOTE: Do not rinse with water immediately after use. INGREDIENTS: 0.12% chlorhexidine gluconate in a base containing water, 11.6% alcohol, glycering, PEG-40 sorbitan diisostearate, flavor, sodium saccharin and FD&C Blue No. 1. To open, press down while turing cap. To reseal, turn cap past "clicks" until tightly locked. Rx Only KEEP OUT OF REACH OF CHILDREN 1 Pint (473 mL) Reorder # [4487-638] 1999BEN16EZCDA Benco 4oz 1 Benco 4oz 2 label Benco 16oz 1 label Benco 16oz 3 Benco 16oz 4
Overview
0.12% chlorhexidine gluconate (CHG) is an oral rinse containing (1,1'-hexamethylene bis [5-(p-chlorophenyl) biguanide] di-D-gluconate) in a base containing water, 11 . 6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium saccharin, and FD&C Blue No.1. Chlorhexidine gluconate product is a near neutral solution (pH range 5-7). Chlorhexidine gluconate is a salt of chlorhexidine and gluconic acid. Its chemical structure is: 0 1
Indications & Usage
INDICATION Chlorhexidine gluconate oral rinse is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. Chlorhexidine gluconate oral rinse has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS .
Dosage & Administration
Chlorhexidine gluconate oral rinse therapy should be initiated directly following a dental prophylaxis. Patients using chlorhexidine gluconate oral rinse should be reevaluated and given a thorough prophylaxis at intervals no longer than six months. Recommended use is twice daily oral rinsing for 30 seconds, morning and evening after tooth brushing. Usual dosage is 15 ml (marked in cap) of undiluted chlorhexidine gluconate oral rinse. Patients should be instructed to not rinse with water, or other mouthwashes, brush teeth, or eat immediately after using chlorhexidine gluconate oral rinse. Chlorhexidine gluconate oral rinse is not intended for ingestion and should be expectorated after rinsing.
Warnings & Precautions
WARNINGS The effect of chlorhexidine gluconate oral rinse on periodontitis has not been determined. An increase in supragingival calculus was noted in clinical testing in chlorhexidine gluconate oral rinse users compared with control users. It is not known if chlorhexidine gluconate oral rinse use results in an increase in subgingival calculus. Calculus deposits should be removed by a dental prophylaxis at intervals not greater than six months. Anaphylaxis, as well serious allergic reactions, have been reported during postmarketing use with dental products containing chlorhexidine. SEE CONTRAINDICATIONS .
Contraindications
Chlorhexidine gluconate oral rinse should not be used by persons who are known to be hypersensitive to chlorhexidine gluconate or other formula ingredients.
Adverse Reactions
The most common side effects associated with chlorhexidine gluconate oral rinses are: 1) an increase in staining of teeth and other oral surfaces; 2) an increase in calculus formation; and 3) an alteration in taste perception; see WARNINGS and PRECAUTIONS . Oral irritation and local allergy-type symptoms have been spontaneously reported as side effects associated with the use of chlorhexidine gluconate rinse. The following oral mucosal side effects were reported during placebo-controlled adult clinical trials: aphthous ulcer, grossly obvious gingivitis, trauma, ulceration, erythema, desquamation, coated tongue, keratinization, geographic tongue, mucocele, and short frenum. Each occurred at a frequency of less than 1%. Among post marketing reports, the most frequently reported oral mucosal symptoms associated with chlorhexidine gluconate oral rinse are stomatitis, gingivitis, glossitis, ulcer, dry mouth, hypesthesia, glossal edema, and paresthesia. Minor irritation and superficial desquamation of the oral mucosa have been noted in patients using chlorhexidine gluconate oral rinse. There have been cases of parotid gland swelling and inflammation of the salivary glands (sialadenitis) reported in patients using chlorhexidine gluconate oral rinse.
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