Refresh Optive Advanced

SPL v11

SPL

SPL Set ID ebd0839e-2e1d-4e0e-986c-19f1f5c76358

Route

OPHTHALMIC

Published

Effective Date 2022-09-15

Document Type 34390-5 HUMAN OTC DRUG LABEL

Drug Facts

Composition & Product

Active Ingredients

Carboxymethylcellulose (5 mg) Glycerin (10 mg) Polysorbate 80

Inactive Ingredients

Boric Acid Carbomer Copolymer Type A (allyl Pentaerythritol Crosslinked) Castor Oil Erythritol Levocarnitine Water Sodium Hydroxide

Identifiers & Packaging

Marketing Status

OTC MONOGRAPH DRUG Active Since 2013-01-15

Description

R efresh OPTIVE® ADVANCED (Preservative-free) Drug Facts

Purpose

Eye lubricant Eye lubricant Eye lubricant

Medication Information

Purpose

Eye lubricant

Description

R efresh OPTIVE® ADVANCED (Preservative-free) Drug Facts

Uses

For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.
May be used as a protectant against further irritation.

Section 42229-5

R efresh OPTIVE® ADVANCED (Preservative-free)

Drug Facts

Warnings

For external use only.
To avoid contamination, do not touch tip of container to any surface. Do not reuse . Once opened, discard.
Do not touch unit-dose tip to eye.
If solution changes color, do not use.

Directions

To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

Other Information

Use only if single-use container is intact.
Use before expiration date marked on container.
Store at 59°-77°F (15°-25°C).
RETAIN THIS CARTON FOR FUTURE REFERENCE.

Active Ingredients

Carboxymethylcellulose sodium 0.5%

Glycerin 1%

Polysorbate 80 0.5%

Inactive Ingredients

Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; and sodium hydroxide (to adjust pH).

Questions Or Comments?

1.800.678.1605

refresh eyedrops .com

v1.0DFL4491

Principal Display Panel

NDC 0023-4491-30

PRESERVATIVE-FREE

Refresh

OPTIVE®

ADVANCED

Lubricant Eye Drops

with Hydrocell®

T riple - A ction R elief

30 Vials

0.01 fl oz (0.4 mL) each Sterile

Stop Use and Ask A Doctor If

you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep Out of Reach of Children.

If swallowed, get medical help or contact a Poison Control Center right away.

Structured Label Content

Uses

For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.
May be used as a protectant against further irritation.

Section 42229-5 (42229-5)

R efresh OPTIVE® ADVANCED (Preservative-free)

Drug Facts

Purpose

Eye lubricant

Warnings

For external use only.
To avoid contamination, do not touch tip of container to any surface. Do not reuse . Once opened, discard.
Do not touch unit-dose tip to eye.
If solution changes color, do not use.

Directions

To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

Other Information (Other information)

Use only if single-use container is intact.
Use before expiration date marked on container.
Store at 59°-77°F (15°-25°C).
RETAIN THIS CARTON FOR FUTURE REFERENCE.

Active Ingredients (Active ingredients)

Carboxymethylcellulose sodium 0.5%

Glycerin 1%

Polysorbate 80 0.5%

Inactive Ingredients (Inactive ingredients)

Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; and sodium hydroxide (to adjust pH).

Questions Or Comments? (Questions or comments?)

1.800.678.1605

refresh eyedrops .com

v1.0DFL4491

Principal Display Panel (PRINCIPAL DISPLAY PANEL)

NDC 0023-4491-30

PRESERVATIVE-FREE

Refresh

OPTIVE®

ADVANCED

Lubricant Eye Drops

with Hydrocell®

T riple - A ction R elief

30 Vials

0.01 fl oz (0.4 mL) each Sterile

Stop Use and Ask A Doctor If (Stop use and ask a doctor if)

you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep Out of Reach of Children. (Keep out of reach of children.)

If swallowed, get medical help or contact a Poison Control Center right away.

Advanced Ingredient Data

[{"name": "carboxymethylcellulose", "unii": "05JZI7B19X", "classCode": "ACTIB", "strengthNumerator": "5", "strengthDenominator": "1", "strengthNumeratorUnit": "mg", "strengthDenominatorUnit": "mL"}, {"name": "glycerin", "unii": "PDC6A3C0OX", "classCode": "ACTIB", "strengthNumerator": "10", "strengthDenominator": "1", "strengthNumeratorUnit": "mg", "strengthDenominatorUnit": "mL"}, {"name": "polysorbate 80", "unii": "6OZP39ZG8H", "classCode": "ACTIB", "strengthNumerator": "5", "strengthDenominator": "1", "strengthNumeratorUnit": "mg", "strengthDenominatorUnit": "mL"}, {"name": "boric acid", "unii": "R57ZHV85D4", "classCode": "IACT", "strengthNumerator": "", "strengthDenominator": "", "strengthNumeratorUnit": "", "strengthDenominatorUnit": ""}, {"name": "CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED)", "unii": "71DD5V995L", "classCode": "IACT", "strengthNumerator": "", "strengthDenominator": "", "strengthNumeratorUnit": "", "strengthDenominatorUnit": ""}, {"name": "castor oil", "unii": "D5340Y2I9G", "classCode": "IACT", "strengthNumerator": "", "strengthDenominator": "", "strengthNumeratorUnit": "", "strengthDenominatorUnit": ""}, {"name": "erythritol", "unii": "RA96B954X6", "classCode": "IACT", "strengthNumerator": "", "strengthDenominator": "", "strengthNumeratorUnit": "", "strengthDenominatorUnit": ""}, {"name": "levocarnitine", "unii": "0G389FZZ9M", "classCode": "IACT", "strengthNumerator": "", "strengthDenominator": "", "strengthNumeratorUnit": "", "strengthDenominatorUnit": ""}, {"name": "water", "unii": "059QF0KO0R", "classCode": "IACT", "strengthNumerator": "", "strengthDenominator": "", "strengthNumeratorUnit": "", "strengthDenominatorUnit": ""}, {"name": "sodium hydroxide", "unii": "55X04QC32I", "classCode": "IACT", "strengthNumerator": "", "strengthDenominator": "", "strengthNumeratorUnit": "", "strengthDenominatorUnit": ""}]

Raw Label Data

All Sections (JSON)

{"Uses": "For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.", "42229-5": "R efresh OPTIVE® ADVANCED (Preservative-free) Drug Facts", "Purpose": "Eye lubricant Eye lubricant Eye lubricant", "Warnings": "For external use only. To avoid contamination, do not touch tip of container to any surface. Do not reuse . Once opened, discard. Do not touch unit-dose tip to eye. If solution changes color, do not use.", "Directions": "To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.", "Other information": "Use only if single-use container is intact. Use before expiration date marked on container. Store at 59°-77°F (15°-25°C). RETAIN THIS CARTON FOR FUTURE REFERENCE.", "Active ingredients": "Carboxymethylcellulose sodium 0.5% Glycerin 1% Polysorbate 80 0.5%", "Inactive ingredients": "Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; and sodium hydroxide (to adjust pH).", "Questions or comments?": "1.800.678.1605 refresh eyedrops .com v1.0DFL4491", "PRINCIPAL DISPLAY PANEL": "NDC 0023-4491-30 PRESERVATIVE-FREE Refresh OPTIVE® ADVANCED Lubricant Eye Drops with Hydrocell® T riple - A ction R elief 30 Vials 0.01 fl oz (0.4 mL) each Sterile ", "Stop use and ask a doctor if": "you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.", "Keep out of reach of children.": "If swallowed, get medical help or contact a Poison Control Center right away."}

Additional Information

Back to search View SPL set listing Open on DailyMed ↗

Source: dailymed · Ingested: 2026-02-15T12:04:37.682377 · Updated: 2026-03-14T23:13:02.501548