bleomycin - Medication Listings

Bleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus . It is freely soluble in water. It is available as a lyophilized powder for intramuscular, intravenous or subcutaneous injection. Each vial contains sterile bleomycin sulphate equivalent to 15 units or 30 units of bleomycin. Sulfuric acid or Sodium hydroxide used, if necessary to adjust the pH. Bleomycins are a group of related basic glycopeptides which differ in the terminal amine substituent of the common structural unit, bleomycin acid. The main components of Bleomycin for Injection are bleomycins A 2 and B 2 . Chemically, bleomycin A 2 is N 1 -[3-(dimethylsulfonio)propyl]-bleomycinamide and bleomycin B 2 is N 1 -[4-(aminoiminomethyl)amino]butyl]-bleomycinamide. The molecular formula of bleomycin A 2 is C 55 H 84 N 17 O 21 S 3 and a calculated molecular weight of 1414. The molecular formula of bleomycin B 2 is C 55 H 84 N 20 O 21 S 2 and a calculated molecular weight of 1425. The structural formula of bleomycins A 2 and B 2 are shown below. Note: A unit of bleomycin is equal to the formerly used milligram activity. The term milligram activity is a misnomer and was changed to units to be more precise. structural formula bleomycin

Bleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus . It is freely soluble in water. Bleomycin for Injection, USP is provided as a sterile lyophilized powder for reconstitution containing 15 units per vial and 30 units per vial, which are intended for intramuscular, intravenous, subcutaneous or intrapleural administration. Its chemical name is N'-[3-(dimethylsulphonio)propyl]bleomycin-amide (bleomycin A 2 ) and N'-[4-(guaniodobutyl)]bleomycin-amide (bleomycin B 2 ). (Main component: Bleomycin A 2 , in which R is [CH 3 ] 2 S + CH 2 CH 2 CH 2 -) Note: A unit of bleomycin is equal to the formerly used milligram activity. The term milligram activity is a misnomer and was changed to units to be more precise. Figure

Bleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus . It is freely soluble in water. Bleomycin for injection is provided as a sterile, white to off-white, lyophilized cake or powder in vials for intramuscular, intravenous, or subcutaneous administration. Each 15 unit and 30 unit vial contains sterile bleomycin sulfate equivalent to 15 or 30 units of bleomycin, respectively. The pH range is 4.0 to 6.0 in a solution reconstituted with Sterile Water for Injection. Its chemical name is N 1 -[3-(dimethylsulphonio)propyl]bleomycin-amide (bleomycin A 2 ) and N 1 -4-(guanidobutyl)bleomycinamide (bleomycin B 2 ). The molecular formula of bleomycin A 2 is C 55 H 84 N 17 O 21 S 3 and a calculated molecular weight of 1414. The molecular formula of bleomycin B 2 is C 55 H 84 N 20 O 21 S 2 and a calculated molecular weight of 1425. The structural formula is shown at right: Note: A unit of bleomycin is equal to the formerly used milligram activity. The term milligram activity is a misnomer and was changed to units to be more precise. Structural Formula

Bleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus . It is freely soluble in water. Bleomycin for Injection, USP is provided as a sterile lyophilized powder for reconstitution containing 15 units per vial and 30 units per vial, which are intended for intramuscular, intravenous, subcutaneous or intrapleural administration. Its chemical name is N’-[3-(dimethylsulphonio)propyl]bleomycin-amide (bleomycin A 2 ) and N’-[4-(guaniodobutyl)]bleomycin-amide (bleomycin B 2 ). (Main component: Bleomycin A 2 , in which R is [CH 3 ] 2 S + CH 2 CH 2 CH 2 -) Note: A unit of bleomycin is equal to the formerly used milligram activity. The term milligram activity is a misnomer and was changed to units to be more precise. structure

Bleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus . It is freely soluble in water. Bleomycin for Injection, USP is provided as a sterile lyophilized powder for reconstitution containing 15 units per vial and 30 units per vial, which are intended for intramuscular, intravenous, subcutaneous or intrapleural administration. Its chemical name is N'-[3-(dimethylsulphonio)propyl]bleomycin-amide (bleomycin A 2 ) and N'-[4-(guaniodobutyl)]bleomycin-amide (bleomycin B 2 ). (Main component: Bleomycin A 2 , in which R is [CH 3 ] 2 S + CH 2 CH 2 CH 2 -) Note: A unit of bleomycin is equal to the formerly used milligram activity. The term milligram activity is a misnomer and was changed to units to be more precise. Chemical Formula

Bleomycin for Injection, USP is a mixture of cytotoxic glycopeptide antibiotics isolated from a strain of Streptomyces verticillus . It is freely soluble in water. It is available as a lyophilized powder for intramuscular, intravenous or subcutaneous injection. Each vial contains sterile bleomycin sulphate equivalent to 15 units or 30 units of bleomycin. Sulfuric acid or Sodium hydroxide used, if necessary to adjust the pH. Bleomycins are a group of related basic glycopeptides which differ in the terminal amine substituent of the common structural unit, bleomycin acid. The main components of Bleomycin for Injection are bleomycins A 2 and B 2 . Chemically, bleomycin A 2 is N 1 -[3-(dimethylsulfonio)propyl]-bleomycinamide and bleomycin B 2 is N 1 -[4-(aminoiminomethyl)amino]butyl]-bleomycinamide. The molecular formula of bleomycin A 2 is C 55 H 84 N 17 O 21 S 3 and a calculated molecular weight of 1414. The molecular formula of bleomycin B 2 is C 55 H 84 N 20 O 21 S 2 and a calculated molecular weight of 1425. The structural formula of bleomycins A 2 and B 2 are shown below. Note: A unit of bleomycin is equal to the formerly used milligram activity. The term milligram activity is a misnomer and was changed to units to be more precise. Chemical Structure