activase - Medication Listings
Browse 1 medications by activase. Open a product record to review strengths, dosage forms, label-backed details, and related navigation.
Alteplase is a tissue plasminogen activator produced by recombinant DNA technology. It is a sterile, purified glycoprotein of 527 amino acids. It is synthesized using the complementary DNA (cDNA) for natural human tissue-type plasminogen activator obtained from a human melanoma cell line. Biological potency is determined by an in vitro clot lysis assay and is expressed in International Units (IU). Activase (alteplase) is a sterile, white to off-white, lyophilized powder for intravenous administration after reconstitution with Sterile Water for Injection, USP. Table 6 Quantitative Composition of the Lyophilized Product 100 mg Vial 50 mg Vial Alteplase 100 mg (58 million IU) 50 mg (29 million IU) L-Arginine 3.5 g 1.7 g Phosphoric Acid 1 g 0.5 g Polysorbate 80 10 mg 5 mg Vacuum No Yes The reconstituted preparation results in a colorless to pale yellow transparent solution containing Activase 1 mg/mL at approximately pH 7.3. The osmolality of this solution is approximately 215 mOsm/kg.
About activase Medications
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